This does not increase your risk of an allergic reaction with the next dose of the COVID-19 vaccine. For Pfizer, 116 cases were reported after the first dose and 372 were reported after the second. 2021 May;157(6):716. doi:10.1001/jamadermatol.2021.1214. Following the second doses of the Moderna vaccines, 12 of these 16 patients ended up having skin reactions again. Delayed localized hypersensitivity reactions to the Moderna COVID-19 vaccine: A case series. After leaving a vaccination provider site, if you think you or your child might be having a severe allergic reaction, seek immediate medical care by calling 911. Delayed localized hypersensitivity reactions to the Moderna COVID-19 vaccine: a case series. Its important to note that you cannot get COVID-19 from any of the approved vaccines. Reports of lymphadenopathy were imbalanced. 11/8/2021 document.addEventListener( 'DOMContentLoaded', function() { However, their reactions to vaccination are expected to be similar to those of young adults who were included. Call your doctor if you think your symptoms are serious. SEATTLE As thousands of people get the COVID-19 vaccine each day, a new but uncommon side effect has emerged among the vaccinated. Reports of lymphadenopathy were imbalanced with 6 more cases in the vaccine group (7) than the placebo group (1); lymphadenopathy is plausibly related to the vaccine. So can having your significant other repeatedly tell you that you dont look that bad. She received her first dose of the Pfizer vaccine and reported local arm soreness. Non-allergic symptoms included numbness, tingling, dizziness, throat tightness, dysphagia, and hypertension, which have all been linked to ISRR, Khalid said. Most side effects come later. Although all of these studies focused on the Moderna vaccine, such skin reactions have occurred with the Pfizer Covid-19 vaccine as well. The majority of systemic events were mild or moderate in severity, after both doses. The researchers found evidence that these symptoms were caused by a delayed allergic reaction. One possible culprit is polyethylene glycol (PEG), which is found in both the Moderna and the Pfizer vaccines. Injection site redness was the second most frequently reported local reaction. If you've had allergic reactions in the past, we want people staying for 30 minutes, Kate Mullane, DO, PharmD, professor of medicine and infectious disease specialist at the University of Chicago, tells Verywell. These quick and witty jokes are easy to memorize and share. As the aforementioned case series showed, not everyone who had such reactions after the first dose necessarily had the same experience following the second dose. Since the first months of the vaccination campaign in various continents, there has been a certain number of reports of adverse events, including skin reactions. ae0fcc31ae342fd3a1346ebb1f342fcb, So due to its uncommonness and successful recovery rate, the CDC still recommends that everyone 12 years and older get vaccinated against COVID. The team noted that delayed cutaneous reactions were only reported in COVID-19 vaccine reports with "rash" or "hives," with a prevalence of 25.5%. No significant atopic history. No other systemic grade 4 reactions were reported. As a result, this causes soreness at the injection site. The. Redness and swelling were slightly more common after dose 2. Severe allergy-like reactions in at least eight people who received the COVID-19 vaccine produced by Pfizer and BioNTech over the past 2 weeks may be due to a compound in the packaging of the messenger RNA (mRNA) that forms the vaccine's main ingredient, scientists say. b Mild: does not interfere with activity; moderate: some interference with activity; severe: prevents daily activity; Grade 4: emergency room visit or hospitalization Researchers Urge Greater Awareness of Delayed Skin Reactions to Moderna COVID-19 Vaccine. Our content is fact checked by our senior editorial staff to reflect accuracy and ensure our readers get But unlike allergic reactions these symptoms do not usually get worse with time, he said. Most SAEs were gastrointestinal or respiratory infections/illnesses that occur commonly in this age group. Different degrees of swelling may be present. Centers for Disease Control and Prevention. The majority of systemic events were mild or moderate in severity, but there was a higher occurrence of grade 3 or higher reactions in the vaccine group. One vaccine recipient reported two SAEs (fever and pain in extremity requiring hospitalization) which were considered potentially related by the investigator and FDA. Consideration for switching to the Johnson & Johnson vaccine? What is the best recommendation regarding a booster vaccine? Overall, the median onset of systemic adverse events in the vaccine group in general was 1 to 2 days after either dose and lasted a median duration of 1 day. COVID-19 vaccine side effects are very common and most often occur after the second dose for those vaccines requiring a two-dose series. Opens in a new tab or window, Visit us on Facebook. 2022 Galvanized Media. Redness was reported slightly more frequently in the older age group than the younger age group (10.9% vs 7.5% after dose 3). But Mullane says not to take it before the shot, as it can interfere with your immune response. Waking up tired with a headache, stomachache, or even the chills the day after you get vaccinated is nothing out of the ordinary. Another possible culprit behind anaphylaxis could be ingredients called lipids. This data is presented in Table 7 below. Is the COVID Vaccine Safe for People With Lung Cancer? Local reactions, systemic reactions, adverse events, and serious adverse events: Pfizer-BioNTech COVID-19 vaccine. Local reactions, systemic reactions, adverse events, and serious adverse events: Pfizer-BioNTech COVID-19 vaccine. Adverse events, including severe allergic reactions, after COVID-19 vaccination are rare but can happen.For this reason, everyone who receives a COVID-19 vaccine is monitored by their vaccination provider for at least 15 minutes. Moving or exercising your arm also may help. Redness and swelling were more common after dose 2 than dose 1 or 3. They "may not have any causal relationship" to each. However, this delayed reaction is still rare. As of right now, most of the post-vaccination myocarditis and pericarditis cases have been reported in male adolescents, more often after the second dose than after the first. Bestlifeonline.com is part of the Meredith Health Group. Rapid elevation in blood pressure and heart rate are also a typical symptom with ISRR reactions, while blood pressure tends to decrease in people experiencing allergic reactions to vaccine, he said. These are not serious and will go away on their own. Pfizer-BioNTech COVID-19 Vaccine (Comirnaty, PF-07302048) Vaccines and Related Biological Products Advisory Committee Briefing Document. COVID arm may appear about seven days after receiving the Moderna vaccine. Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years experience in consumer-oriented health and wellness content. Overall, the median onset of systemic adverse events in the vaccine group in general was 1 to 4 days after either dose and lasted a median duration of 1 day. There is no data on which to base a decision about administering an alternative vaccine and I think it is unlikely that this approach would have a different outcome since your patient has reacted to non-COVID-19 vaccines in a similar manner. Als u uw keuzes wilt aanpassen, klik dan op 'Privacyinstellingen beheren'. c Mild: 2 to 3 loose stools in 24 hours; moderate: 4 to 5 loose stools in 24 hours; severe: 6 or more loose stools in 24 hours; Grade 4: emergency room visit or hospitalization for severe diarrhea. NEW YORK and MAINZ, GERMANY, February 24, 2023 - Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced they have submitted a supplemental Biologics License Application (sBLA) to the U.S. Food and Drug Administration (FDA) for approval of their Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine as a primary series and booster dose(s) for individuals 12 years of age and older. Some who received their first shot of the Moderna vaccine said their. Bei der Nutzung unserer Websites und Apps verwenden wir, unsere Websites und Apps fr Sie bereitzustellen, Nutzer zu authentifizieren, Sicherheitsmanahmen anzuwenden und Spam und Missbrauch zu verhindern, und, Ihre Nutzung unserer Websites und Apps zu messen, personalisierte Werbung und Inhalte auf der Grundlage von Interessenprofilen anzuzeigen, die Effektivitt von personalisierten Anzeigen und Inhalten zu messen, sowie, unsere Produkte und Dienstleistungen zu entwickeln und zu verbessern. March 1, 2023. Jacqueline A. Pongracic, MD, FAAAAI. An additional four had pre-existing allergies to antibiotics. Muscle and joint pain. Fever was more common after the second dose than after the first dose. The symptoms can last on average 3-4 weeks but may resolve more rapidly. Common side effects of Pfizer COVID vaccine The Therapeutic Goods Administration lists "very common side effects" of the Pfizer vaccine as: pain/swelling at injection site tiredness headache muscle pain chills fever joint pain Got questions about the COVID vaccines? These zingers are to-the-point and easy to remember. if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { None of the participants had received the Pfizer-BioNTech vaccine. "The known and potential benefits of COVID-19 vaccination outweigh the known and potential risks, including the possible risk of myocarditis or pericarditis," the CDC states on its website. The double-blind study included 16 adults (15 women and 1 man) who had experienced systemic allergic reactions soon after receiving their first dose of Pfizer/BioNTech or Moderna's COVID-19 vaccines. For Pfizer, 116 cases were reported after the first dose and 372 were reported after the second. On day nine developed myalgias, arthralgias (no arthritis), unilateral upper and lower eyelid edema. Thirteen of the 16 study participants went on to receive a third, unblinded booster dose of the mRNA vaccine in the supervised medical setting, and 10 developed symptoms consistent with ISRR, with a median symptom onset of 7 minutes. Currently, the vaccine is authorized for those as young as 12. Safe and effective vaccination has become the most important tool to control and prevent the spread of SARS-CoV-2 infection. Swollen lymph nodes (typically manifests as a lump in your armpit or above your collarbone) The side effects are similar for the three vaccines and are an indication that the vaccines are helping to build protection against disease. The urticaria can be generalised and intensely itchy. Miller and colleagues noted that incidence of . It can be quite uncomfortable too. Having a delayed skin reaction to one dose of the Covid-19 vaccines doesnt mean you should avoid subsequent doses like the booster either. Although you feel terrible, it's a good thing, because those systemic effects are telling you that your body is making an immune reaction, Mullane says. There's no need to worry about any of the flu-like symptoms. a Mild: does not interfere with activity; moderate: some interference with activity; severe: prevents daily activity; Grade 4: emergency room visit or hospitalization for severe fatigue, severe headache, severe muscle pain, or severe joint pain. The most common solicited systemic adverse reaction after any dose was irritability (43.6% 51.2%) among ages 6 23 months and fatigue (24.5% 29.7%) among ages 2 4 years. Memorial Sloan Kettering Cancer Center. RELATED:If You Got This Vaccine, You May Have Low Antibodies Against the India Variant. The most common were fatigue, headache, and new or worsened muscle pain. There is no evidence to . These latter types of cells handle delayed hypersensitivity. We know from the CDC that is so rare and it's in the range of 1 to 5 per million people depending on which vaccine you get with the Pfizer or the Moderna." Both medical experts pointed out. We have answers Confused about Australia's vaccine rollout? Thirteen participants (0.9%) in the vaccine group and 1 participant (0.1%) in the placebo group had events of lymphadenopathy. Most likely these reactions are the result of whats called delayed T-cell-mediated hypersensitivity. One study showed that 70% and 75% of participants reported soreness at the injection site after the first and second doses, respectively. It also is possible to have a breakthrough infection, which means you have COVID even though you got the vaccine. The overall incidence of unsolicited non-serious adverse events from dose 1 to data cutoff (April 29, 2022) were similar in the vaccine and placebo groups in both age groups: 29.1% vs. 26.3% for the younger age group and 18.5% vs. 18.5% in the older age group, respectively. You can count on these short math quips for a good chuckle. Swollen Lymph Nodes After COVID-19 Vaccines May Cause Mammogram Confusion, NSAIDs (Advil, Motrin) May Dampen the Antibody Response to COVID-19 Vaccines. According to Khan, there's good news from the findings: "The vast majority of patients who've had reactions which they think are allergic can actually receive subsequent vaccinations, and do this . Thats why they tell you to wait around the vaccination location for 15 minutes following the shot and not 11,520 minutes. The US Food and Drug Administration (FDA) has said there are three delayed side effects that may happen to people who get the Pfizer or Moderna vaccine. Of the 22 allergic reactions occurring within 3 hours of receiving a vaccine dose, 20 occurred in women. (Table 6). Cookies used to make website functionality more relevant to you. A systemic allergic reaction to a vaccine occurs in one or more parts of the body beyond the injection site. You could use the word urticaria to describe many of these rashes. She developed what sounds like an Arthus reaction to the tetanus vaccine in childhood. cMild: 2 to 3 loose stools in 24 hours; moderate: 4 to 5 loose stools in 24 hours; severe: 6 or more loose stools in 24 hours; Grade 4: emergency room visit or hospitalization for severe diarrhea. For most people, this means some mild symptoms like a sore arm, or flu-like symptoms that last up to two days before going away. With the COVID-19 vaccine, this reaction can be delayed 7-10 days without any symptoms prior to this. The CDC Says This Delayed Vaccine Side Effect Is Showing Up More Often Now, This Vaccine Reaction Means You May Have Already Had COVID, Study Says, If You Got This Vaccine, You May Have Low Antibodies Against the India Variant, For more up-to-date information, sign up for our But you can have a skin reaction that only appears eight days or more post-vaccination. RELATED:This Vaccine Reaction Means You May Have Already Had COVID, Study Says. They were not a contraindication to subsequent vaccination, although patients should be counseled with regard to the possibility of recurrence. 4 Some less common side effects include nausea and swollen lymph nodes (especially in the armpit). Serious adverse events were defined as any untoward medical occurrence that resulted in death, was life-threatening, required inpatient hospitalization or prolongation of existing hospitalization, or resulted in persistent disability or incapacity. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. The most common were fatigue, headache, and new or worsened muscle pain. If you or your child feel like you are experiencing any of these symptoms within a week after the COVID vaccination, the CDC says you should seek medical care. A research letter published in theNew England Journal of Medicine in April 2021did describe 12 patients who developed rashes after getting the Moderna Covid-19 vaccines. Four of these patients had had a history of seasonal allergies. Instead, it describes a whole set of immune system responses that dont begin until at least 12 hours after its encountered a potential invader. Delayed-onset injection site reactions that started after the first 7 days, including pain, redness or swelling, occurred in 0.8% of adults after the first dose, and 0.2% after the second dose. They include: If you still have severe symptoms two full days after your vaccination, you may want to talk with your doctor to see what to do next. The study authors also mention that samples taken from skin biopsies confirmed their suspicion of a delayed allergic immune response that is commonly seen in drug reactions. Even if the side effect were linked to the vaccine, a single case report wont tell you how rare the side effect may be. Eczema and the COVID-19 Vaccine: Is it Safe? Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. Use of COVID-19 vaccines after reports of adverse events among adult recipients of Janssen (Johnson & Johnson) and mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna): Update from the Advisory Committee on Immunization Practices United States, July 2021, 5 exercises to reduce arm soreness after the COVID-19 vaccination, The second dose of a COVID-19 vaccine: Side effects, why they happen, and how to treat them, Reactogenicity following receipt of MRNA-based COVID-19 vaccines, Delayed localized hypersensitivity reactions to the Moderna COVID-19 vaccine: a case series. A Timeline of COVID-19 Vaccine Side Effects. "People were already under stress due to COVID, and they were getting a brand new vaccine and hearing about adverse reactions," Khalid said. Unless your patient's maculopapular rash progressed to Stevens Johnson Syndrome or involved the mucosa, and since the reaction clearly was not anaphylactic, such a reaction is not an absolute contraindication to subsequent vaccination. COVID-19 vaccines can cause mild side effects after the first or second dose, including: Pain, redness or swelling where the shot was given Fever Fatigue Headache Muscle pain Chills Joint pain Nausea and vomiting Swollen lymph nodes Feeling unwell Most side effects go away in a few days. xhr.send(payload); Out of 475 reported cases of myocarditis or pericarditis in individuals 30 years or younger, 81 percent fully recovered. cMild: 2 to 3 loose stools in 24 hours; moderate: 4 to 5 loose stools in 24 hours; severe: 6 or more loose stools in 24 hours; Grade 4: emergency room visit or hospitalization for severe diarrhea. Opens in a new tab or window, Visit us on TikTok. The WHO report highlights common differences in presentation, including: Khalid said that use of rescue epinephrine can be reduced by carefully monitoring patient reactions, although he acknowledged the challenges in distinguishing between vaccine-related anaphylaxis and ISRR. First Time Around Group; Breastfeeding Support; Cardio and Pulmonary Service. Remember that with the two-dose vaccines like Pfizer-BioNTech and Moderna, you may notice more side effects after the second shot. Centers for Disease Control and Prevention. She developed a distal rash one day after her initial injection. 3. SAN FRANCISCO -- As more. All vaccinations occurred at the intensive care unit of the NIH Clinical Center in Bethesda, Maryland, under close medical supervision and monitoring. According to the Heart, Lung, and Blood Institute, myocarditis. Mar 9, 2021. Opens in a new tab or window. Reports of lymphadenopathy were imbalanced with 58 more cases in the vaccine group (64) than the placebo group (6); lymphadenopathy is plausibly related to the vaccine. aMild: 0.5 to 2.0 cm; moderate: >2.0 to 7.0 cm; severe: >7.0 cm; Grade 4: necrosis (redness and swelling categories) or exfoliative dermatitis (redness category only). It's much more common to feel some soreness in your arm at the injection site, and the surrounding skin may get a little red and swollen. The frequency of systemic adverse events was higher in the younger than the older age group (82.8% vs 70.6%). This site uses cookies. Delayed urticaria following a COVID-19 vaccine Acute urticaria can occur 1-2 weeks following vaccination. If your patient decides to pursue a booster dose, I think supportive care for symptom management with acetaminophen or NSAIDs could be considered. Now, there are reports of a skin rash at the injection site and the timing of. Delayed reaction after COVID-19 vaccination 11/8/2021 A 59-year-old female with medical history of hypothyroidism, celiac disease, osteopenia, and obstructive sleep apnea was referred to my office to discuss an adverse reaction to the second dose of the Pfizer COVID-19 mRNA vaccine. Enfermedades de Inmunodeficiencia Primaria, AAAAI Diversity Equity and Inclusion Statement, https://www.cdc.gov/vaccines/covid-19/clinical-considerations/covid-19-vaccines-us.html#Appendix-B, Delayed reaction after COVID-19 vaccination. Thank you, {{form.email}}, for signing up. Therefore, a T-cell responses would probably be to one of the following: the mRNA, the lipid nanoparticle that encapsulates and helps deliver the mRNA, the solution that carries these nanoparticles in the vaccine, or the spike protein that your cells produce using the mRNA as blueprints. These delayed reactions are also not allergic reactions and do not impact the ability of the patient to receive the second dose of vaccine. More than half of the reported cases of heart inflammation after the COVID vaccine have been in the 16 to 24 age group. Typically, theyve been itchy, painful or both rather than hilarious, exciting, sensual, or empowering. Five of these rashes appeared eight days or more post-vaccination. Although this type of reaction can be uncomfortable, it is not an allergic reaction to the vaccine. Few SAEs were reported from dose 1 to data cutoff (April 29, 2022) among the vaccine and placebo groups, (1.4% and 2.3%, respectively in the younger age group and 0.7% and 0.9%, respectively in the older age group). Some side effects happen right after your shot, like mild pain in your arm. var payload = 'v=1&tid=UA-72659260-1&cid=778575c4-54eb-4775-8be5-9d909a1b97ce&t=event&ec=clone&ea=hostname&el=domain&aip=1&ds=web&z=1968823626136046333'.replace( 'domain', location.hostname ); SAN ANTONIO -- Many reported anaphylactic reactions to COVID-19 vaccination may in fact be attributable to vaccine-induced immunization stress-related response (ISRR), suggested findings from a small study presented here. According to the FDA's vaccine fact sheet, typical side effects of the Pfizer-BioNTech vaccine include: tiredness headache fever chills muscle or joint pain nausea diarrhea swollen lymph. Opens in a new tab or window, Visit us on LinkedIn. People commonly report systemic side effects, like fever, headaches, muscle aches, joint pain, chills, and fatigue. if( navigator.sendBeacon ) { Can People With MS Get the COVID-19 Vaccine? A 59-year-old female with medical history of hypothyroidism, celiac disease, osteopenia, and obstructive sleep apnea was referred to my office to discuss an adverse reaction to the second dose of the Pfizer COVID-19 mRNA vaccine. By age group, 88.7% in the younger group (aged 18 to 55 years) and 79.7% in the older group (aged >55 years) reported at least one local reaction. The risk of anaphylaxisa severe allergic reaction to the vaccineis lower just 15 to 30 minutes after vaccination. "Very often that's a delayed reaction," he said: Someone might take an antibiotic for a skin condition and, six weeks later, end up in hospital with damage to a major organ, like a kidney or. "We clearly have an imbalance there," Tom Shimabukuro, MD, the deputy director of the CDC's Immunization Safety Office, said during the meeting, as reported by Reuters. The fever resolved in 24 hours. The double-blind study included 16 adults (15 women and 1 man) who had experienced systemic allergic reactions soon after receiving their first dose of Pfizer/BioNTech or Moderna's COVID-19 vaccines. Now there is a case report in the journal Cureus that described a man in his early 20s whos suffered whats been called chronic urticaria because his symptoms had been persistent. Serious adverse events were defined as any untoward medical occurrence that resulted in death, was life-threatening, required inpatient hospitalization or prolongation of existing hospitalization, or resulted in persistent disability/incapacity. Once these body-wide side effects set in, they can last for 12 hours or more. Vomiting and diarrhea were exceptions, and similar between vaccine and placebo groups and regardless of dose. Fatigue, headache, chills, and new or worsened muscle pain were most common. However, it can take up to two weeks after the second shot of the two-dose vaccines, or the single dose of the Johnson & Johnson, to mount a full immune response. Centers for Disease Control and Prevention. c Mild: 1 to 2 times in 24 hours; moderate: >2 times in 24 hours; severe: requires intravenous hydration; Grade 4: emergency room visit or hospitalization However, their reactions to vaccination are expected to be similar to those of young adults who were included. Strong prevaccination anxiety and history of allergy were found to be . Source Reference: Khalid M, et al "COVID-19 mRNA vaccine-induced immunization stress-related response (ISRR) and anaphylaxis: an early look at COVAAR clinical outcomes" AAAAI 2023. Some people who get the Moderna vaccinemay experience "COVID arm," a delayed skin reaction with raised, red welts on the arm. d Mild: easily consolable; moderate: requiring increased attention; severe: inconsolable; crying cannot be comforted; Grade 4: emergency room visit or hospitalization, aAny fever= 38.0C This reaction is very rare, but the CDC requires everyone who gets the vaccine to wait in the clinic for 15 minutes after getting the shot, just in case it happens. Some of the side effects of the COVID-19 vaccines have become well-known, such as symptoms like fever and chills. 2020 . And for Moderna, 100 cases were reported after the first dose and 201 were reported after the second. Within each age group, the frequency and severity of systemic adverse events was higher after dose 2 than dose 1. March 3, 2021 Some people are having delayed reactions to their first dose of a Covid vaccine, with their arms turning red, sore, itchy and swollen a week or so after the shot. In nearly all cases, the rashes appeared a lot sooner (within three days for all but one) following the second dose. b Mild: 1 to 2 times in 24 hours; moderate: >2 times in 24 hours; severe: requires intravenous hydration; Grade 4: emergency room visit or hospitalization for severe vomiting. She developed on day 8 local swelling, rash, and itching at injection site (Not concerned). Out of more than 141 million fully vaccinated individuals, there have been a total of 789 reported cases of myocarditis or pericarditis as of May 31, per the CDC. Indeed, a February 2021 publication in the New England Journal of Medicine showed that immediate skin reactions were relatively common, occurring in 12,765 (84.2%) of the 15,168 participants who had received the first dose of the Moderna Covid-19 mRNA vaccine in a clinical trial. This research was funded by the National Institute of Allergy and Infectious Diseases. Full coverage and live updates on the Coronavirus. Its possible that while you had vaccine side effects, you were also ill with COVID-19 or a different infection. Wenn Sie Ihre Auswahl anpassen mchten, klicken Sie auf Datenschutzeinstellungen verwalten. A team from the Massachusetts General Hospital (Kimberly G. Blumenthal, MD, Esther E. Freeman, MD, PhD, Rebecca R. Saff, MD, PhD, Lacey B. Robinson, MD, MPH Anna R. Wolfson, MD, Ruth K. Foreman, MD, PhD, Aleena Banerji, MD, Erica S. Shenoy, MD, PhD), Mass General Brigham (Dean Hashimoto, MD), Brigham and Womens Hospital (Lily Li, MD) and the Baylor College of Medicine (Sara Anvari, MD) co-authored this letter. ", In a 2019 report, the World Health Organization (WHO) first proposed the term "immunization-stress related response" to refer to "any untoward medical occurrence which follows immunization and which does not necessarily have a causal relationship with the usage of the vaccine.". The time or intensity with which peoples immune systems respond to vaccines can differ based on many factors. We discussed that the presentation sounds more consistent with a serum sickness-like reaction versus an IgE mediated allergic reaction. Delayed reactions with pain, redness and swelling at the injection site have been seen up to 7 to 10 days after vaccination. In rare cases, a serious reaction or complication may follow COVID vaccination. Patients with Remarkable, Delayed, Large Local Reactions to the mRNA-1273 Vaccine. Local reactions such as arm pain, swelling and redness after vaccination with the Pfizer COVID-19 shot first appeared any time between 0 (the day of vaccination) and two days after being.
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